What Are Polynucleotides: Unlocking Advanced Skin Rejuvenation
This article explains what are polynucleotides, detailing their origin from highly purified salmon DNA fragments. These injectable bio-stimulators work at a cellular level, promoting skin rejuvenation by stimulating collagen and elastin production. Readers will learn how these DNA fragments act as PDRN, enhancing cell regeneration, deep hydration, and providing antioxidant protection. The content explores how salmon DNA injections effectively treat various skin concerns, improving overall skin quality and offering a comprehensive anti-ageing treatment. It also highlights the specific benefits of Plinest injections in aesthetic medicine.
Aesthetic Clinic Rejuva London specializes in advanced regenerative aesthetics, offering expert insights into treatments like polynucleotide therapy. This content provides factual information on how these bio-revitalisation techniques support natural skin repair and enhance skin health.
To explore your options, contact us to schedule your consultation. You can also reach us via: Book a Clinic Consultation, Contact Us via WhatsApp (+44 7415972345)
Polynucleotides are injectable bio-stimulators for cellular regeneration. Derived from highly purified salmon DNA fragments, these treatments provide the building blocks skin needs to repair itself, boost collagen and elastin, and improve overall skin health.
What Exactly Are Polynucleotides? Understanding the Science
Polynucleotides are injectable, gel-like substances composed of long chains of nucleotides, the building blocks of DNA. They are sourced from salmon because their DNA is similar to human DNA, ensuring biocompatibility and minimizing the risk of adverse reactions. Unlike dermal fillers that add volume, these DNA fragments act as bio-stimulators, signalling skin to repair and regenerate at a cellular level.
The Role of PDRN and DNA Fragments in Skin Regeneration
The active component is Polydeoxyribonucleotide (PDRN), a polynucleotide subtype studied for its wound-healing and tissue-repair properties. The controlled extraction and purification process isolates these DNA fragments, removing proteins and other components that could cause an immune response. The result is a sterile, absorbable product that triggers cell regeneration. For a more detailed overview, see our complete guide to polynucleotide therapy.
How Do Salmon DNA Injections Rejuvenate Skin at a Cellular Level?
The four primary actions of polynucleotides on the skin are:
- Fibroblast Stimulation: They bind to receptors on fibroblast cells, signalling them to produce more collagen and elastin. This restores the skin’s structural framework, increasing firmness and elasticity.
- Deep Hydration: The long polynucleotide chains have a high water-binding capacity. This hydrophilic property draws and holds moisture within the skin, improving skin texture and plumpness.
- Antioxidant Effect: Polynucleotides act as “free radical scavengers.” They neutralize free radicals caused by UV radiation and pollution, protecting skin cells from oxidative stress and premature ageing.
- Tissue Repair: They provide the building blocks to support tissue repair and the growth of new skin cells.
What Skin Concerns Can Polynucleotides Effectively Treat?
Polynucleotides are a versatile anti-ageing treatment for a wide range of skin concerns, particularly for improving skin quality and addressing loss of elasticity and thinning skin. They are effective where traditional volumizing fillers may not be the appropriate or desired solution.
The table below outlines common concerns and how this regenerative therapy provides a targeted solution.
Targeting Delicate Areas: Under-Eyes, Neck, and Décolletage
Polynucleotides are well-suited for treating delicate areas like the periorbital (under-eye) region, the neck, and the décolletage, where skin is thinner and more prone to fine lines and crepiness. The treatment’s ability to thicken the dermis and improve skin structure makes it a preferred option for rejuvenation in these areas, especially compared to traditional tear trough fillers that can cause puffiness or a bluish tinge (the Tyndall effect).
Plinest Polynucleotides: The Rejuva London Difference in Regenerative Aesthetics
At Rejuva London, we select products for patient safety and superior outcomes. For polynucleotide therapy, we use Plinest from the Italian pharmaceutical company Mastelli. With over 70 years of research and more than 100 published clinical studies, Plinest has established purity, safety, and efficacy. Its development is backed by scientific evidence, with research available from the National Center for Biotechnology Information (NCBI).
Why Our Doctor-Led Clinic Prioritizes Plinest for Optimal Results
Our founder, Dr. Kristy Lau, and our team of medical doctors prioritize treatments for natural regeneration. Plinest injections use Mastelli’s proprietary HPT™ (Highly Purified Technology) for a product of high purity and a specific molecular weight optimized for bio-revitalisation. This precision minimizes inflammatory responses and maximizes fibroblast stimulation. Administered by our doctors at our 15 Harley Street clinic, this ensures an effective treatment that adheres to high medical safety standards.
What to Expect: The Polynucleotide Treatment Journey & Results Timeline
Treatment begins with a medical consultation. At Rejuva London, this includes a VISIA Skin Analysis to assess your skin’s condition and establish a baseline. Our doctors use this to create a personalized treatment plan.
A typical treatment course is 2-3 sessions spaced 3-4 weeks apart. Injections are administered with a fine needle or cannula for comfort and precision, especially around the eyes. While initial hydration benefits may be noticeable within weeks, regenerative effects appear gradually. Improvements in texture, firmness, and radiance appear over 2-3 months as skin produces new collagen and elastin. Results are long-lasting, with a maintenance session recommended every 6-9 months.
Understanding Your Personalized Treatment Plan and Aftercare
After treatment, minor redness, swelling, or small bumps may appear at the injection sites, typically resolving within 24-48 hours. Our doctors provide aftercare instructions, which include avoiding strenuous exercise, extreme temperatures, and certain skincare products for a short period. Following this guidance supports the skin’s regenerative process for your anti-ageing treatments.
Ready to Rejuvenate Your Skin? Book Your Expert Polynucleotide Consultation
Polynucleotide therapy is a science-backed approach to restoring skin health at a cellular level. It is a potential solution for concerns like under-eye circles, crepey skin, or loss of elasticity. Our doctor-led clinic on Harley Street provides a high standard of care with evidence-based treatments like Plinest.
To determine if polynucleotides are right for your skin, contact us to schedule a consultation. You can Book a Clinic Consultation online or Contact Us via WhatsApp (+44 7415972345).
Frequently Asked Questions
In simple terms, what are polynucleotides?
Polynucleotides are highly purified fragments of DNA, often sourced from salmon, that act as bio-stimulators. When injected, they provide the building blocks for your skin cells to repair damage, produce collagen, and deeply hydrate. Understanding what are polynucleotides is key to seeing how they regenerate skin from within.
Beyond the basic definition, what are polynucleotides in terms of skin treatment?
As a skin treatment, these DNA fragments work at a cellular level by stimulating fibroblast cells—the factories for collagen and elastin. This process thickens and strengthens the skin, improves elasticity, and reduces fine lines. Knowing what are polynucleotides helps you understand their role in improving your skin’s own health and structure.
If they are not fillers, then what are polynucleotides compared to other injectables?
Unlike dermal fillers that add volume, this treatment is fundamentally different because it is a regenerative therapy. It improves your skin’s own health and structure from within, rather than just filling a space. The answer to what are polynucleotides lies in their bio-stimulatory and reparative action on your cells.
What skin concerns can this regenerative treatment address?
This bio-stimulatory treatment is highly effective for a range of concerns, including fine lines and wrinkles, under-eye circles, poor skin texture, and dehydration. It can also be used to improve the appearance of acne scars and restore overall skin radiance and elasticity.
How long does it take to see results from salmon DNA injections?
While some initial improvement in hydration may be noticeable, the true regenerative effects appear gradually. Since the treatment relies on your body’s natural collagen production, optimal results are typically seen over several weeks to months after a course of sessions.
How can I find out if polynucleotide injections are right for me?
The best way to determine your suitability is through an expert consultation at our Harley Street clinic. Our doctors perform a data-driven VISIA skin analysis to assess your needs and create a safe, effective treatment plan. You can book a clinic consultation to discuss your goals with our medical team.
