Rejuva London Harley Street
Rejuva London Harley Street
nasolabial fold filler erase smile lines permanently

Nasolabial Fold Filler: Erase Smile Lines Permanently

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Please consult with a qualified medical professional for personalized assessment and treatment recommendations.

Medical Review: This article has been medically reviewed and approved by Dr. Kristy Lau.

Nov 21, 2025

Nov 21, 2025

Nasolabial Fold Fillers: Restore Youthful Contours Without Surgery

Are deepening smile lines making you appear tired or older than you feel? Nasolabial folds – those lines running from your nose to the corners of your mouth – are natural facial features that can become more pronounced with age, often causing self-consciousness and affecting confidence in social and professional settings.

At Rejuva London’s Harley Street clinic, we offer advanced dermal filler treatments specifically designed to soften these lines while maintaining your natural facial expressions. Our doctor-led approach ensures precise injection techniques that address not just the visible fold but the underlying structural changes causing it.

Treatment is quick (typically 20-30 minutes), involves minimal discomfort thanks to ultra-fine needles and integrated anaesthetic, and allows you to return to normal activities immediately. While you may experience mild swelling or occasional bruising, these effects typically resolve within 24-48 hours.

Our philosophy prioritizes subtle, natural-looking results that enhance your features rather than changing them. You’ll still look like yourself – just a more refreshed, rejuvenated version that better reflects your inner vitality.

To discover if nasolabial fold fillers are right for you, book a personalised consultation with our medical aesthetic specialist who will assess your unique facial anatomy and develop a tailored treatment plan for your specific concerns.

Table of Contents

Understanding Nasolabial Folds and Their Impact on Facial Appearance

As a medical aesthetic specialist with over 10 years of experience, I’ve observed how nasolabial folds significantly impact facial appearance and my patients’ confidence. These prominent lines running from the sides of the nose to the corners of the mouth are often called “smile lines” or “laugh lines,” but their deepening with age can create an appearance that doesn’t reflect one’s inner vitality.

Nasolabial folds are natural anatomical features present in everyone, even children. However, as we age, these lines become more pronounced due to several factors including collagen loss, decreased skin elasticity, and facial fat redistribution. When these folds deepen, they can create a tired, aged appearance that many of my Harley Street patients find concerning.

The impact of pronounced nasolabial folds extends beyond physical appearance. Many patients at our London clinic report feeling that these lines make them look perpetually tired or unhappy, even when they’re feeling quite the opposite. This disconnect between inner vitality and outer appearance can affect social interactions and self-confidence.

At Rejuva London, I approach nasolabial fold treatment with a comprehensive understanding of facial anatomy. These folds aren’t isolated features but part of the midface structure that changes holistically with age. This anatomical perspective is crucial for achieving natural-looking results with nasolabial fold fillers that harmonise with the entire face rather than simply “filling a line.”

What Causes Deepening Smile Lines and Marionette Lines?

The progressive deepening of smile lines and the development of marionette lines (the lines that run from the corners of the mouth to the chin) stem from multiple age-related changes that I observe daily in my clinical practice. Understanding these causes is essential for effective treatment planning.

The primary factors contributing to deepening facial folds include:

  • Collagen and elastin depletion: After age 25, we lose approximately 1% of our collagen annually, accelerating to 2-3% loss per year after menopause for women. This structural protein decline leads to skin laxity and fold deepening.
  • Midface volume loss: The fat pads that provide youthful facial contours gradually diminish and shift downward, creating hollows in the cheek area that exaggerate nasolabial folds.
  • Bone resorption: Our facial skeleton actually changes with age, with the maxilla (upper jaw) and other facial bones losing volume, providing less structural support for overlying tissues.
  • Repeated facial expressions: Years of smiling, laughing, and other expressions create memory lines in the skin that eventually become permanent.
  • Environmental factors: Sun exposure, smoking, and pollution accelerate collagen breakdown and contribute to premature aging around the mouth and nose.

Marionette lines develop through similar mechanisms but are particularly influenced by the downward migration of facial tissues and the loss of support at the corners of the mouth. These lines can create a downturned appearance that patients often describe as making them look sad or angry when they’re not.

At our Harley Street clinic, I assess each of these factors individually to create a personalised treatment approach for each patient seeking smile lines treatment or marionette line correction.

How Dermal Fillers Work to Correct Facial Wrinkles and Folds

Dermal fillers represent one of the most effective non-surgical approaches to correcting nasolabial folds and other facial wrinkles. As a doctor-led clinic, I believe in educating patients about exactly how these treatments work to create natural-looking rejuvenation.

Modern dermal fillers used for nasolabial fold treatment are primarily composed of hyaluronic acid (HA), a naturally occurring substance in our skin that binds water molecules and provides volume and hydration. When strategically injected, these fillers work through several mechanisms:

  • Immediate volume restoration: The filler material physically fills depressed areas, providing immediate structural support beneath the fold.
  • Collagen stimulation: Quality HA fillers trigger a mild inflammatory response that stimulates your body’s natural collagen production, creating longer-term improvements.
  • Hydration enhancement: Hyaluronic acid’s remarkable ability to attract and hold up to 1,000 times its weight in water improves skin quality and suppleness in the treated area.
  • Tissue repositioning: When placed in specific anatomical planes, fillers can actually lift and reposition descended tissue, addressing the root cause of fold formation.

What makes dermal fillers particularly effective for nasolabial fold correction is their versatility. At Rejuva London, I carefully select filler viscosity, cohesivity, and placement depth based on the specific characteristics of each patient’s folds. For superficial lines, I might choose a softer, more fluid filler placed closer to the skin surface. For deeper structural support, a firmer filler with greater lifting capacity placed at the periosteal level might be more appropriate.

This customised approach to dermal filler treatments allows me to address not just the visible fold but the underlying structural changes causing it, creating more natural and harmonious results.

What is the Best Filler for Nasolabial Fold Treatment?

As a medical practitioner specialising in facial aesthetics, I’m often asked, “What is the best filler for nasolabial folds?” The answer isn’t one-size-fits-all, as the optimal choice depends on several patient-specific factors. However, I can provide guidance on the most effective options we use at our Harley Street clinic.

Hyaluronic acid fillers remain the gold standard for nasolabial fold treatment due to their safety profile, natural integration with tissues, and reversibility if needed. Within this category, several formulations excel for different fold characteristics:

Filler TypeBest ForLongevityKey Benefits
Juvederm Volift/VolumaModerate to deep folds requiring structural support12-18 monthsExcellent lifting capacity, natural movement
Restylane Lyft/DefyneDefined folds with good skin quality9-12 monthsPrecise placement, less water absorption
Belotero BalanceFine, superficial lines alongside deeper folds6-9 monthsIntegrates seamlessly with tissues, no Tyndall effect
Radiesse (CaHA)Deep folds with significant volume loss12-15 monthsImmediate correction plus collagen stimulation

For optimal results, I often employ a layered approach, using different filler types at various depths. For example, a firmer filler might be placed deep along the bone to provide structural support, while a softer, more flexible product addresses the superficial aspects of the fold.

The “best” filler also depends on your aesthetic goals, budget considerations, and tolerance for maintenance treatments. During your consultation at Rejuva London, I conduct a thorough assessment of your facial anatomy, skin quality, and the specific characteristics of your nasolabial folds to recommend the most appropriate filler or combination of products.

The Nasolabial Fold Filler Procedure: What to Expect

At Rejuva London, I personally perform all injectable treatments, ensuring the highest standards of safety and precision for nasolabial fold filler procedures. Here’s what you can expect when you visit our Harley Street clinic:

Before Your Treatment

Your journey begins with a comprehensive consultation where I assess your facial anatomy, discuss your concerns, and explain suitable treatment options. I’ll take photographs for clinical documentation and develop a personalised treatment plan. To prepare for your procedure, you should avoid blood-thinning medications, alcohol, and certain supplements for 48 hours before treatment to minimise bruising risk.

During Your Procedure

The nasolabial fold filler treatment itself typically takes 20-30 minutes and follows these steps:

  1. Thorough cleansing of the treatment area
  2. Application of topical anaesthetic cream (if desired) for 15-20 minutes
  3. Marking of precise injection points
  4. Strategic injection of the selected filler using either a fine needle or cannula technique
  5. Gentle massage to ensure even distribution and natural contours
  6. Application of arnica gel or cold compress to minimise swelling

Most patients ask if smile line fillers hurt. While there may be mild discomfort, modern fillers contain lidocaine (a local anaesthetic) that significantly reduces pain during injection. Many patients describe the sensation as a slight pressure or pinch rather than sharp pain.

Typical Amount of Filler Required

For nasolabial folds, the amount of filler needed typically ranges from 0.5ml to 2ml total (for both sides), depending on the depth of folds and whether adjacent areas like the midface require treatment for optimal results. I follow a conservative approach, sometimes scheduling a follow-up session for additional product if needed rather than over-filling in a single visit.

Immediately after treatment, you can expect some redness, possible minor swelling or bruising, and immediate improvement in the appearance of your nasolabial folds. You’ll receive detailed aftercare instructions and can return to most normal activities right away.

Achieving Natural-Looking Results with Anti-Aging Fillers

The hallmark of excellent nasolabial fold treatment is achieving results that appear completely natural. As a medical doctor specialising in facial aesthetics, my philosophy centres on enhancement rather than alteration – helping you look like a refreshed version of yourself, not a different person entirely.

The key principles I follow to ensure natural-looking results with anti-aging fillers include:

Respecting Facial Anatomy

Natural results begin with a deep understanding of facial anatomy. Rather than simply filling the visible line, I assess how the nasolabial fold relates to surrounding structures. Often, the most natural correction comes from addressing midface volume loss that causes the fold to appear more pronounced, rather than injecting directly into the fold itself.

Strategic Placement Techniques

The technique matters as much as the product. I employ several advanced methods:

  • Layered approach: Placing filler at different tissue depths to create natural dimension
  • Vectoring technique: Injecting along specific directional vectors to lift tissues rather than just filling them
  • Cannula delivery: Using blunt-tipped cannulas for certain areas to reduce trauma and allow more precise product placement

Appropriate Product Selection

Different areas of the face require fillers with specific properties. For nasolabial folds, I select products that integrate seamlessly with facial movements, avoiding the stiff or puffy appearance that can result from using inappropriate fillers.

Conservative Approach

I firmly believe in the “less is more” philosophy. It’s always preferable to start conservatively and add more product if needed rather than risking an overfilled appearance. This measured approach ensures subtle enhancement that friends and colleagues might notice as a refreshed appearance without identifying specific treatments.

At Rejuva London, we regularly see patients seeking correction of overfilled nasolabial folds performed elsewhere. The art of natural facial rejuvenation lies not in eliminating every line but in softening them appropriately while maintaining the character and expressiveness that makes each face unique.

How Long Do Smile Line Fillers Last? Maintenance Guide

One of the most common questions my patients ask about nasolabial fold fillers concerns their longevity. Understanding the expected duration of results helps in planning both financially and practically for maintaining your refreshed appearance.

The longevity of smile line fillers depends on several factors:

FactorImpact on Longevity
Filler TypeDifferent formulations have varying breakdown rates in the body
Injection DepthDeeper placements typically last longer than superficial ones
MetabolismPatients with higher metabolic rates may break down fillers more quickly
Facial MovementAreas with significant movement (like around the mouth) metabolise filler faster
Lifestyle FactorsSun exposure, smoking, and intense exercise can accelerate filler breakdown

Generally, hyaluronic acid fillers used for nasolabial folds last between 6-18 months, with most patients seeing optimal results for approximately 9-12 months. Calcium hydroxylapatite fillers (like Radiesse) may last slightly longer, typically 12-15 months.

Recommended Maintenance Schedule

For sustained results, I recommend the following maintenance approach:

  1. Initial follow-up: 2-4 weeks after treatment to assess results and add small amounts of product if necessary
  2. Maintenance treatments: Every 9-12 months before the product fully dissipates
  3. Comprehensive reassessment: Every 2-3 years to evaluate changing facial anatomy and adjust treatment strategies

Many patients find that with regular maintenance, they actually need less product over time. This occurs because hyaluronic acid fillers stimulate collagen production, creating subtle structural improvements that persist even as the filler itself dissolves.

To extend the longevity of your nasolabial fold treatment, I recommend diligent sun protection, a quality skincare regimen including retinoids and antioxidants, adequate hydration, and avoiding excessive facial movements like repetitive facial expressions during the first week after treatment.

Comparing Fillers to Other Facial Rejuvenation Options

While dermal fillers are excellent for addressing nasolabial folds, they represent just one option in the spectrum of facial rejuvenation treatments. As a medical practitioner committed to comprehensive care, I believe in presenting patients with all suitable options to make informed decisions.

Here’s how fillers compare to alternative treatments for addressing smile lines and facial wrinkles:

TreatmentBest ForResults TimelineLongevityDowntime
Dermal FillersModerate to deep folds, volume lossImmediate6-18 monthsMinimal (0-2 days)
Botulinum Toxin (Botox)Dynamic lines, prevention of fold deepening3-7 days3-4 monthsNone
Ultherapy/ThermageSkin laxity, early fold formation2-3 months1-2 yearsMinimal (0-3 days)
Thread LiftingModerate sagging, fold supportImmediate1-3 yearsModerate (3-7 days)
Laser ResurfacingSkin texture, fine lines alongside folds1-3 months1-5 yearsSignificant (7-14 days)

At Rejuva London, I often recommend combination approaches for optimal results. For example, a patient with pronounced nasolabial folds might benefit from:

  • Dermal fillers to address volume loss in the midface and directly soften the fold
  • Ultherapy to improve skin elasticity and provide long-term lifting
  • PicoSure Pro laser treatments to enhance skin quality and address fine lines

The ideal treatment plan depends on several factors including the anatomical cause of your nasolabial folds, your aesthetic goals, budget considerations, and tolerance for downtime. During your consultation at our Harley Street clinic, I conduct a thorough assessment to recommend the most appropriate treatment or combination of treatments for your specific concerns.

For patients seeking the most natural-looking results with minimal downtime, dermal fillers remain the gold standard for nasolabial fold correction, offering immediate improvement with excellent safety profiles when administered by a qualified medical professional.

To discuss which treatment option is best suited for your nasolabial folds and other facial rejuvenation goals, book a consultation at our Harley Street clinic today.

Frequently Asked Questions

What is the best filler for nasolabial folds?

The best filler for nasolabial folds depends on your specific anatomy and the depth of your folds. Hyaluronic acid fillers like Juvederm Volift/Voluma and Restylane Lyft/Defyne are generally considered optimal choices due to their natural integration, safety profile, and reversibility. For moderate to deep folds requiring structural support, Juvederm Voluma offers excellent lifting capacity with results lasting 12-18 months. For more defined folds with good skin quality, Restylane products provide precise placement with 9-12 months longevity. During your consultation at Rejuva London, I’ll assess your unique facial structure to recommend the most appropriate filler for your specific needs.

How long do smile line fillers last?

Smile line fillers typically last between 6-18 months, with most patients experiencing optimal results for approximately 9-12 months. The longevity varies based on several factors including the specific filler used, injection depth, your metabolism, facial movement patterns, and lifestyle factors like sun exposure and smoking. Hyaluronic acid fillers used for nasolabial folds generally provide results for 9-12 months, while calcium hydroxylapatite fillers (Radiesse) may last 12-15 months. For sustained results, I recommend maintenance treatments every 9-12 months before the product fully dissipates, with many patients finding they need less product over time as collagen stimulation creates lasting structural improvements.

Can nasolabial fold fillers look natural?

Yes, nasolabial fold fillers can look completely natural when performed by an experienced medical practitioner using appropriate techniques and products. The key to natural-looking results lies in respecting facial anatomy rather than simply filling the visible line. At Rejuva London, I achieve natural outcomes through strategic placement techniques including a layered approach at different tissue depths, vectoring techniques that lift tissues rather than just filling them, and selecting products that integrate seamlessly with facial movements. I firmly believe in a conservative “less is more” approach, starting with modest correction and adding more product if needed rather than risking an overfilled appearance that can look artificial.

Do smile line fillers hurt?

Smile line fillers cause minimal discomfort for most patients. Modern dermal fillers contain lidocaine (a local anesthetic) that significantly reduces pain during injection. Additionally, at Rejuva London, I apply topical numbing cream before treatment if desired, which further minimizes sensation. Most patients describe the experience as a slight pressure or pinch rather than sharp pain. The procedure is quick, typically taking only 20-30 minutes, and any mild discomfort resolves immediately after treatment. For patients with particular sensitivity, I can employ additional comfort measures including ice application and specialized injection techniques using fine cannulas that cause less trauma than traditional needles.

How much filler is needed for nasolabial folds?

The amount of filler needed for nasolabial folds typically ranges from 0.5ml to 2ml total (for both sides), depending on the depth of your folds and whether adjacent areas require treatment for optimal results. Mild folds may need only 0.5-1ml total, while moderate to severe folds often require 1-2ml for comprehensive correction. At Rejuva London, I follow a conservative approach, sometimes scheduling a follow-up session for additional product rather than over-filling in a single visit. This patient-specific approach ensures natural-looking results while addressing the structural causes of nasolabial folds, not just the visible lines themselves.

Dr. Kristy Lau, Medical Director of Rejuva London

Dr. Kristy Lau

Medical Director & Founder

Aesthetic Clinic London

MBBS Imperial College London
GMC Registered
30+ Years Medical Experience

Dr. Kristy Lau is the founder and Medical Director of

Rejuva London Clinic
, an

Imperial College London

graduate with over 10 years of comprehensive medical expertise. Specializing in dermatology and medical aesthetics, Dr. Lau combines rigorous medical training with advanced aesthetic technologies to deliver personalized, natural-looking treatments.

At Rejuva London’s prestigious Harley Street location, Dr. Lau ensures all procedures are performed exclusively by highly experienced doctors, maintaining the highest standards of safety and excellence in aesthetic medicine. Her doctor-led approach has successfully treated over 20,000 clients since establishing the clinic in 2018.

Medical Specializations:

Injectable Treatments
  • Anti-wrinkle Injections (Botox)
  • Dermal Fillers
  • Facial Contouring
Advanced Technologies
  • Picosure Pro Laser
  • Thermage RF
  • Ultherapy
Medical Dermatology
  • Skin Health Assessment
  • Medical Aesthetics
  • Laser Skin Treatments

Professional Qualifications & Credentials:

  • Medical Degree
    MBBS, Imperial College London
  • Professional Registration
    GMC Registered Medical Practitioner
  • Specialization
    General Practice (GP) Certification
  • Advanced Training
    Dermatology & Aesthetic Medicine Specialization

About Rejuva London

Established in on prestigious Harley Street,
Rejuva London has served over 20,000 clients through our doctor-led approach to aesthetic medicine.

Aesthetic Clinic London:
15 Harley Street
London
W1G 9QQ
United Kingdom

20,000+Clients Treated
6+Years of Excellence
100%Doctor-Led

Treatment Philosophy:

“My approach to aesthetic medicine centers on enhancing natural beauty while prioritizing patient safety.
Every treatment at Rejuva London is tailored to the individual, combining medical expertise with artistic
vision to achieve results that look naturally refreshed, never overdone.”
– Dr. Kristy Lau

Professional Memberships & Affiliations:

  • General Medical Council (GMC)
  • British College of Aesthetic Medicine
  • British Association of Cosmetic Doctors

Consult with Dr. Lau in Aesthetic Clinic in London:

Experience the Rejuva London difference with a personalized consultation