Rejuva London Harley Street
Rejuva London Harley Street
Polynucleotide Contraindications Medical Consultation

Contraindications for Polynucleotide Therapy: What to Disclose to Your Doctor

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Please consult with a qualified medical professional for personalized assessment and treatment recommendations.

Medical Review: This article has been medically reviewed and approved by Dr. Kristy Lau.

May 12, 2026

May 12, 2026

Polynucleotide Contraindications: Ensuring Safe Aesthetic Treatment

Understanding polynucleotide contraindications is essential for safe and effective aesthetic treatment. These are specific health conditions or medical history factors that may prevent or require caution with polynucleotide injections. Key absolute contraindications include pregnancy, breastfeeding, active skin infections, and known allergies to product components like fish. Relative contraindications, such as certain autoimmune diseases, necessitate a detailed medical assessment. Disclosing a comprehensive medical history is crucial for determining polynucleotide safety and suitability, ensuring patient well-being.

Rejuva London, a doctor-led aesthetic clinic on Harley Street, prioritizes patient safety through rigorous medical consultations. Their expert approach ensures that all polynucleotide treatments are precisely tailored to individual health profiles, minimizing risks and optimizing regenerative outcomes.

To explore your options, contact us to schedule your consultation. You can also reach us via: Book a Polynucleotide Consultation

Understanding polynucleotide contraindications is critical for safety and optimal results. A thorough medical history disclosure is the foundation of a safe treatment plan. This guide from Rejuva London, a doctor-led aesthetic clinic on Harley Street, outlines conditions that may prevent or require caution with polynucleotide injections, enabling an informed discussion with your medical professional.

What Are Polynucleotide Contraindications?

A contraindication is a condition where a procedure should not be used because it may be harmful. For polynucleotide therapy, these are health or medical history factors that increase the risk of adverse effects and help determine who is an ideal candidate for polynucleotide injections.

Primary absolute contraindications for polynucleotide treatment include:

  • Pregnancy or breastfeeding
  • Active skin infection or inflammation in the treatment area
  • Known allergy to the product’s components (e.g., fish/salmon)
  • Severe, uncontrolled systemic diseases

Absolute vs. Relative Contraindications Explained

Absolute contraindications are conditions where treatment must not be performed due to a high risk of serious harm. Relative contraindications mean caution is required; treatment may be possible, but a qualified doctor must weigh the benefits against the potential risks.

Your Medical History and The Rejuva London Consultation

A pre-treatment consultation is a critical safety step where a medical professional assesses your health, discusses your goals, and identifies potential polynucleotide contraindications.

The Doctor-Led Difference: Precision in Patient Safety Assessment

At Rejuva London, only medical doctors perform injectable procedures. This policy ensures the person assessing your suitability has the medical training to understand complex health histories. Our founder, Dr. Kristy Lau, a graduate of Imperial College London, has instilled a culture of rigorous medical assessment. A doctor can interpret how a past illness or current medication might impact an aesthetic treatment, an insight crucial for patient safety.

What to Disclose: Beyond the Obvious for Your Safety

Be prepared to discuss the following with your doctor:

  • All past and present medical conditions, including autoimmune disorders, skin conditions, and bleeding disorders.
  • A complete list of all prescription medications, over-the-counter drugs, and dietary supplements you are taking.
  • Any known allergies, including foods, medications, or environmental allergens.
  • Your history with past aesthetic treatments, both injectable and non-injectable, and how your body responded.
  • Any recent illnesses or upcoming surgeries.

The Doctor-Led Approach to Safety

Patient safety extends beyond the initial consultation to include treatment planning, product selection, and post-treatment care protocols to minimize risks.

Rigorous Screening and Personalized Treatment Planning

After a thorough consultation, a personalized treatment plan is developed. This plan details specific precautions if any relative contraindications are present. At Rejuva London, we use Plinest, a purified, medical-grade polynucleotide product with a strong safety record. This choice is part of our risk-management strategy to ensure product purity and safety.

Managing Potential Risks and Post-Treatment Care

Minor side effects like swelling, redness, or bruising can occur. A doctor-led clinic is equipped to manage these outcomes and differentiate them from rare complications. You will receive clear aftercare instructions. Our clinical protocols, from skin preparation to post-injection care, are designed to maximize safety and deliver consistent results.

Your Medical History and The Rejuva London Consultation — Contraindications for Polynucleotide Therapy: What to Disclose to Your Doctor
Expected timeline for the resolution of common, mild side effects following polynucleotide injections.

Booking Your Polynucleotide Consultation

A consultation with a qualified medical doctor is the only way to determine if polynucleotide therapy is a safe and suitable option for you. It is an opportunity to ask questions and receive a professional medical opinion based on your health profile.

Schedule Your Personalized Assessment at Harley Street

If you are considering polynucleotides for skin regeneration, schedule an assessment at our Harley Street clinic. Our medical team will conduct a thorough evaluation to ensure your safety and create a tailored treatment plan. Learn more about our approach at Rejuva London or Book a Polynucleotide Consultation.

Your Safety is the Priority

Understanding polynucleotide contraindications and being transparent with your doctor are cornerstones of a safe outcome. Choosing a doctor-led clinic ensures your health is prioritized. To begin with a team that places medical expertise at the forefront, Book a Polynucleotide Consultation at our clinic on Harley Street.

Frequently Asked Questions

What are the main polynucleotide contraindications to be aware of?

The primary polynucleotide contraindications include pregnancy, breastfeeding, active skin infections or inflammation in the treatment area, and known severe allergies to the product’s components. A full medical history must be discussed with your doctor during your consultation to ensure this regenerative treatment is safe and appropriate for you.

Is a severe fish allergy one of the key polynucleotide contraindications?

Yes, this is a critical point to discuss with your doctor. Although medical-grade polynucleotides are highly purified to remove allergenic proteins, a history of severe fish or seafood allergy is often considered one of the key polynucleotide contraindications. Your doctor will perform a detailed risk assessment based on your specific allergy history.

Can I have polynucleotides if I have an autoimmune disease?

This requires careful medical evaluation by a qualified doctor. While treatment may be possible for certain stable autoimmune conditions, an active or uncontrolled autoimmune disease is a significant reason to avoid this therapy. Patient safety is the absolute priority, and a thorough assessment is essential.

Why must I disclose all medications when discussing polynucleotide contraindications?

Disclosing all medications is vital for your safety, as it helps identify potential polynucleotide contraindications or risks. For instance, blood-thinning medications like aspirin or warfarin can significantly increase the risk of bruising at the injection sites. Your doctor needs this information to provide correct pre-treatment advice and ensure a safe procedure.

What happens if I have a condition that prevents treatment?

If you have a firm contraindication for polynucleotide therapy, our doctors will prioritise your safety and will not proceed with the treatment. They will explain the reasoning clearly and can then discuss alternative, safer regenerative treatments that are suitable for your specific medical profile and aesthetic goals.

How can I determine if I am a suitable candidate for polynucleotide treatment?

The best way to determine your suitability is to schedule a comprehensive consultation with a medical doctor. At our Harley Street clinic, a doctor will thoroughly assess your medical history and skin to confirm if polynucleotide therapy is safe for you. Book a polynucleotide consultation to have your questions answered by an expert.

Dr. Kristy Lau, Medical Director of Rejuva London

Dr. Kristy Lau

Medical Director & Founder

Aesthetic Clinic London

MBBS Imperial College London
GMC Registered
30+ Years Medical Experience

Dr. Kristy Lau is the founder and Medical Director of

Rejuva London Clinic
, an

Imperial College London

graduate with over 10 years of comprehensive medical expertise. Specializing in dermatology and medical aesthetics, Dr. Lau combines rigorous medical training with advanced aesthetic technologies to deliver personalized, natural-looking treatments.

At Rejuva London’s prestigious Harley Street location, Dr. Lau ensures all procedures are performed exclusively by highly experienced doctors, maintaining the highest standards of safety and excellence in aesthetic medicine. Her doctor-led approach has successfully treated over 20,000 clients since establishing the clinic in 2018.

Medical Specializations:

Injectable Treatments
  • Anti-wrinkle Injections (Botox)
  • Dermal Fillers
  • Facial Contouring
Advanced Technologies
  • Picosure Pro Laser
  • Thermage RF
  • Ultherapy
Medical Dermatology
  • Skin Health Assessment
  • Medical Aesthetics
  • Laser Skin Treatments

Professional Qualifications & Credentials:

  • Medical Degree
    MBBS, Imperial College London
  • Professional Registration
    GMC Registered Medical Practitioner
  • Specialization
    General Practice (GP) Certification
  • Advanced Training
    Dermatology & Aesthetic Medicine Specialization

About Rejuva London

Established in on prestigious Harley Street,
Rejuva London has served over 20,000 clients through our doctor-led approach to aesthetic medicine.

Aesthetic Clinic London:
15 Harley Street
London
W1G 9QQ
United Kingdom

20,000+Clients Treated
6+Years of Excellence
100%Doctor-Led

Treatment Philosophy:

“My approach to aesthetic medicine centers on enhancing natural beauty while prioritizing patient safety.
Every treatment at Rejuva London is tailored to the individual, combining medical expertise with artistic
vision to achieve results that look naturally refreshed, never overdone.”
– Dr. Kristy Lau

Professional Memberships & Affiliations:

  • General Medical Council (GMC)
  • British College of Aesthetic Medicine
  • British Association of Cosmetic Doctors

Consult with Dr. Lau in Aesthetic Clinic in London:

Experience the Rejuva London difference with a personalized consultation