Rejuva London Harley Street
Rejuva London Harley Street
polynucleotide eye treatment advanced under eye rejuvenation

Polynucleotide Eye Treatment: Advanced Under-Eye Rejuvenation

Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Please consult with a qualified medical professional for personalized assessment and treatment recommendations.

Medical Review: This article has been medically reviewed and approved by Dr. Kristy Lau.

Mar 10, 2026

Mar 10, 2026

Polynucleotide Eye Treatment: Natural Rejuvenation

This comprehensive guide to Polynucleotide Eye Treatment explains the science, benefits, and process behind this advanced therapy for the under-eye area. We distinguish our approach by emphasising our doctor-led, regenerative philosophy and the exacting safety standards of a prestigious Harley Street clinic. You will learn how this treatment provides natural, restorative outcomes for dark circles and fine lines, empowering you to make a confident decision about your care.

Your treatment is performed exclusively by our Medical Director, Dr. Kristy Lau, whose expertise is grounded in dermatology training from Imperial College London. As the ‘Best Anti-Ageing Clinic London 2025’, Rejuva London ensures every procedure is doctor-led for unparalleled safety. We are committed to a restorative philosophy that delivers natural, regenerative results from our renowned Harley Street location, assuring you that you are in the most trusted hands.

To begin your journey towards restored confidence and natural beauty, book your consultation at our Harley Street clinic today.

Table of Contents

What Is Polynucleotide Treatment for the Under-Eye Area?

Polynucleotide (PN) treatment is a sophisticated, bio-regenerative injectable designed to rejuvenate the delicate under-eye skin at a cellular level. Unlike fillers, it does not add artificial volume but instead uses purified DNA fragments to stimulate your skin’s natural repair mechanisms, enhancing skin quality, hydration, and firmness from within.

At Rejuva London, this advanced treatment represents the pinnacle of restorative aesthetics. This PN periorbital treatment works by signalling your cells to produce more collagen and elastin, the essential building blocks of youthful, resilient skin. It improves microcirculation, which can help reduce the vascular component of dark circles, and provides deep hydration to smooth away fine lines and crepey texture. This approach is ideal for patients seeking a natural, long-term improvement in the health and appearance of the skin around their eyes. The PN under eye treatment is meticulously administered to repair and revitalise tissue, addressing concerns like skin laxity, dehydration, and signs of fatigue without altering your natural facial contours.

The Complete Doctor’s Guide to Polynucleotide Therapy: How Salmon DNA Bio-Stimulators Repair Skin

How Do Polynucleotides Regenerate and Restore the Eye Area?

The mechanism of polynucleotides aligns perfectly with Rejuva London’s core philosophy of “Rejuvenation, Regenerative, and Restoration.” This treatment is not a temporary cosmetic fix; it is a profound process of eye area regeneration that empowers your skin to heal and rebuild itself. The polynucleotide chains act as a bio-revitalising agent, delivering a trio of powerful effects at the cellular level.

Firstly, they provide a structural scaffold for fibroblasts, the critical cells responsible for producing collagen and elastin. By binding with water molecules, they create a deeply hydrated environment that is optimal for cellular function. This intense hydration plumps the skin from within, immediately improving its texture. Secondly, polynucleotides have a potent antioxidant effect, neutralising damaging free radicals that accelerate ageing and contribute to skin dullness. This protects the delicate under-eye skin from environmental stressors. Most importantly, they signal the fibroblasts to increase production of Type I collagen and elastin. This biological stimulation leads to a gradual thickening and strengthening of the skin, which helps to conceal underlying blood vessels that cause dark circles and improves overall skin resilience. This regenerative approach to treating polynucleotide dark circles ensures results are not only visible but also sustainable, promoting long-term skin health.

Are You a Suitable Candidate for This Eye Rejuvenation?

A comprehensive consultation with Dr. Kristy Lau is the definitive way to determine your suitability for a polynucleotide eye treatment. However, this regenerative therapy is particularly effective for individuals concerned with the quality and texture of their under-eye skin. Ideal candidates typically present with one or more of the following concerns:

  • Fine lines, wrinkles, and crepey skin around the eyes.
  • Mild to moderate skin laxity in the periorbital area.
  • Dark circles caused by thin, translucent skin or poor microcirculation.
  • Dehydrated, dull, or tired-looking under-eye skin.
  • Those seeking a natural improvement without the use of volumising fillers.

It is important to understand the distinction between this treatment and traditional fillers. While polynucleotides are excellent for improving skin health and density, they do not add significant volume. For concerns related to deep hollows or volume loss in the tear trough, an alternative to filler may sometimes be more appropriate, or a combination approach may be recommended. The polynucleotide tear trough treatment can prepare the skin by improving its integrity, making subsequent treatments more effective. Conversely, this treatment is less suitable for addressing significant polynucleotide eye bags caused by herniated fat pads, which typically require a surgical approach. During your consultation, Dr. Lau will conduct a thorough assessment to recommend the most effective and safest treatment plan for your unique anatomy and goals.

Your Treatment Journey: A Focus on Doctor-Led Safety

At Rejuva London, patient safety and clinical excellence are the cornerstones of our practice. Your entire polynucleotide treatment journey, from the initial assessment to the final injection, is personally managed and performed by our Medical Director, Dr. Kristy Lau. With over 30 years of medical experience and a background in dermatology from Imperial College London, Dr. Lau’s expertise ensures your treatment is not only effective but also conducted under the strictest medical safety protocols.

Your journey begins with an in-depth consultation. Dr. Lau will assess your skin quality, discuss your concerns, and review your medical history to confirm that PN treatment is safe and appropriate for you. This is a crucial step to create a personalised treatment plan tailored to your specific needs. On the day of the treatment, the under-eye area is cleansed, and a topical anaesthetic cream is applied to ensure your comfort. Dr. Lau then uses a series of precise, micro-injections to deliver the polynucleotide serum to the target areas. Her meticulous technique minimises discomfort and risk, which is paramount when treating the delicate eye area. A course of 2-3 sessions, spaced 2-4 weeks apart, is typically recommended to achieve optimal, lasting results. This doctor-led approach provides unparalleled peace of mind, assuring you that you are in the safest, most experienced hands.

What Natural, Restorative Results Can I Expect to See?

The results from a PN under eye treatment unfold gradually as your skin’s regenerative processes are activated. This ensures the outcome is exceptionally natural, refreshing your appearance without any sign of artificial enhancement. Patients at our Harley Street clinic report a significant improvement in the overall health and vitality of their skin. Following a complete course of treatment, you can expect to see:

  • Reduced Appearance of Dark Circles: By increasing skin thickness and improving microcirculation, the treatment helps to mask the underlying blood vessels, leading to a brighter, less tired appearance. This is a key benefit for those struggling with polynucleotide dark circles.
  • Softening of Fine Lines and Wrinkles: The stimulation of new collagen and elastin fibres works to smooth out crepey texture and fine lines, restoring a more youthful and rested look to the eye area.
  • Improved Skin Hydration and Elasticity: The potent hydrating properties of polynucleotides leave the skin feeling deeply moisturised, supple, and firm.
  • Enhanced Skin Texture and Radiance: The overall skin quality is refined, resulting in a smoother, more luminous complexion that reflects light better.
  • Long-Term Skin Health Benefits: By repairing skin at a cellular level, the treatment provides long-lasting structural improvements, with results typically maintained for 6-12 months before a top-up session is recommended.

Understanding the Risks & Aftercare for Polynucleotide Injections

While polynucleotide treatment is recognised for its high safety profile, particularly in experienced medical hands, it is essential for patients to be fully informed about potential side effects and the required aftercare. At Rejuva London, transparency and patient well-being are paramount. The procedure involves injections, and as such, some minor and temporary side effects are common and should be expected.

Potential side effects include:

  • Bruising and Swelling: This is the most common reaction. Small bumps or slight swelling may appear at the injection sites, typically resolving within 24-72 hours.
  • Redness and Tenderness: The treated area may feel slightly tender or appear red immediately after the procedure, but this usually subsides within a few hours.
  • Rare Complications: While extremely rare when performed by a qualified medical professional like Dr. Kristy Lau, risks can include infection or the formation of persistent nodules. Our stringent hygiene standards and expert technique significantly minimise these risks.

Post-Treatment Aftercare

To ensure the best possible results and a smooth recovery, we advise you to follow these guidelines:

  • Avoid touching or rubbing the treated area for at least 4-6 hours.
  • Refrain from strenuous exercise, saunas, steam rooms, and excessive sun exposure for 24-48 hours.
  • Avoid applying makeup to the area for at least 12 hours post-treatment.
  • Apply a cool compress gently if you experience swelling, but avoid direct pressure.

A full aftercare plan will be provided to you following your treatment at our clinic.

Why Choose a Harley Street Clinic for Your Eye Treatment?

Choosing where to have a delicate procedure like a Polynucleotide Eye Treatment is the most critical decision you will make. The location of your clinic is a direct reflection of the standards of care you can expect. Situated in the world-renowned Harley Street medical district, Rejuva London provides a level of clinical excellence and patient safety that is simply unparalleled. This prestigious address is synonymous with the highest calibre of medical expertise, attracting leading specialists from around the globe.

When you choose our award-winning Harley Street clinic, you are entrusting your care to an institution recognised for its commitment to quality. Rejuva London was proudly named the “Best Anti-Ageing Clinic – London 2025,” an accolade that underscores our dedication to innovative, effective, and safe aesthetic treatments. Here, every procedure is performed in a clinical, regulated environment by highly qualified doctors like Dr. Kristy Lau. This doctor-led ethos ensures that your safety is never compromised. In an industry with varying levels of regulation, selecting a Harley Street clinic like Rejuva London guarantees that your treatment is conducted with meticulous attention to detail, using authentic, premium products and adhering to the strictest medical protocols for a safe and restorative outcome.

Begin Your Rejuvenation Journey with an Expert Consultation

The first step towards revitalising your delicate eye area is a private, comprehensive consultation with Dr. Kristy Lau. At Rejuva London, we believe in a personalised, educational approach where your unique concerns are heard and your aesthetic goals are understood. During your consultation, Dr. Lau will assess your skin’s condition and determine if polynucleotide eye treatment is the ideal solution to restore a brighter, more youthful appearance. This is your opportunity to ask questions and gain the confidence that comes from being under the care of a true expert in the field of aesthetic medicine. To start your journey, contact us today and arrange your bespoke consultation.

To discover a personalised, natural approach to aesthetics, book a consultation with our expert medical team at Rejuva London’s award-winning Harley Street clinic.

Frequently Asked Questions About Polynucleotide Eye Treatments

How many polynucleotide sessions are needed for the under-eye area?

For optimal and lasting under-eye rejuvenation, a course of two to three polynucleotide treatment sessions is typically recommended, spaced approximately three to four weeks apart. This protocol allows for the cumulative stimulation of collagen and elastin, ensuring a comprehensive and restorative outcome for the delicate periorbital skin.

During your initial consultation at our Harley Street clinic, Dr. Lau will create a bespoke treatment plan, as the precise number of sessions depends on your unique skin condition and aesthetic goals. A maintenance session may be advised every 6-12 months.

How do polynucleotides differ from tear trough fillers?

Polynucleotides are bio-stimulators that work at a cellular level to repair tissue and encourage your skin to produce its own collagen, improving skin quality, texture, and hydration. Unlike tear trough fillers, they do not add artificial volume or hyaluronic acid to fill hollows but instead focus on deep skin regeneration.

This makes them an ideal treatment for addressing skin laxity, crepiness, and dark circles caused by thin skin. For deep, structural hollows, dermal fillers may be a more appropriate alternative, which Dr. Lau will expertly assess during your consultation.

How long do the results of under-eye polynucleotide treatment last?

The restorative results from a full course of polynucleotide treatments can last between six to twelve months, as the treatment stimulates your body’s natural regenerative processes. The skin’s improved health, hydration, and elasticity are gradual and long-lasting, promoting a sustained youthful and rested appearance around the eyes.

To maintain these benefits and continue to support cellular health, we typically recommend a single maintenance session every 6 to 12 months, as advised by your doctor.

Is the polynucleotide eye treatment painful?

The polynucleotide eye treatment involves minimal discomfort, which is managed effectively to ensure a comfortable experience at our Harley Street clinic. A topical anaesthetic cream is applied to the treatment area beforehand, and the injections themselves are administered with a very fine needle to ensure precision and comfort.

Most patients report a mild, fleeting sensation, but the procedure is generally very well-tolerated. Dr. Lau’s precise and gentle technique, honed over 30 years, further minimises any potential discomfort.

What is the downtime after a PN eye treatment?

There is typically minimal to no social downtime required following a polynucleotide eye treatment, allowing you to resume most daily activities immediately. You may experience some mild, temporary swelling, redness, or tiny bumps at the injection sites, which are common and usually subside within 24 to 72 hours.

We advise against strenuous exercise, saunas, and applying makeup for the first 24 hours to ensure the best possible outcome and minimise the risk of bruising.

When will I see results from my polynucleotide treatment?

Initial improvements in skin hydration and texture can often be noticed within a few weeks of your first session. As polynucleotides work by stimulating your body’s natural regenerative cycle, the full, optimal results—such as improved skin firmness and reduced fine lines—typically become visible around three months after your final treatment.

The results are progressive, meaning your skin quality will continue to improve over time as new, healthy collagen and elastin are produced for a truly natural and lasting effect.

Dr. Kristy Lau, Medical Director of Rejuva London

Dr. Kristy Lau

Medical Director & Founder

Aesthetic Clinic London

MBBS Imperial College London
GMC Registered
30+ Years Medical Experience

Dr. Kristy Lau is the founder and Medical Director of

Rejuva London Clinic
, an

Imperial College London

graduate with over 10 years of comprehensive medical expertise. Specializing in dermatology and medical aesthetics, Dr. Lau combines rigorous medical training with advanced aesthetic technologies to deliver personalized, natural-looking treatments.

At Rejuva London’s prestigious Harley Street location, Dr. Lau ensures all procedures are performed exclusively by highly experienced doctors, maintaining the highest standards of safety and excellence in aesthetic medicine. Her doctor-led approach has successfully treated over 20,000 clients since establishing the clinic in 2018.

Medical Specializations:

Injectable Treatments
  • Anti-wrinkle Injections (Botox)
  • Dermal Fillers
  • Facial Contouring
Advanced Technologies
  • Picosure Pro Laser
  • Thermage RF
  • Ultherapy
Medical Dermatology
  • Skin Health Assessment
  • Medical Aesthetics
  • Laser Skin Treatments

Professional Qualifications & Credentials:

  • Medical Degree
    MBBS, Imperial College London
  • Professional Registration
    GMC Registered Medical Practitioner
  • Specialization
    General Practice (GP) Certification
  • Advanced Training
    Dermatology & Aesthetic Medicine Specialization

About Rejuva London

Established in on prestigious Harley Street,
Rejuva London has served over 20,000 clients through our doctor-led approach to aesthetic medicine.

Aesthetic Clinic London:
15 Harley Street
London
W1G 9QQ
United Kingdom

20,000+Clients Treated
6+Years of Excellence
100%Doctor-Led

Treatment Philosophy:

“My approach to aesthetic medicine centers on enhancing natural beauty while prioritizing patient safety.
Every treatment at Rejuva London is tailored to the individual, combining medical expertise with artistic
vision to achieve results that look naturally refreshed, never overdone.”
– Dr. Kristy Lau

Professional Memberships & Affiliations:

  • General Medical Council (GMC)
  • British College of Aesthetic Medicine
  • British Association of Cosmetic Doctors

Consult with Dr. Lau in Aesthetic Clinic in London:

Experience the Rejuva London difference with a personalized consultation